In this interrupted case study, students assume the role of a first-year resident whose first patient arrives by ambulance with a suspected myocardial infarction (MI) in progress. Students consider which clinical tests would be helpful to confirm the diagnosis of MI and then review patient data and lab results. Next, the resident meets a second patient, a woman presenting with classic MI symptoms. The patient is admitted, and tests are administered; however, this time results do not come back clearly matching a typical heart attack. Designed to teach students about myocardial infarction, the case provides basics on the identification and treatment of this in a hospital setting, and introduces students to takotsubo cardiomyopathy. Prior to using the case, students should have general knowledge of cardiac function and be familiar with a typical ECG trace, but they do not need to have extensive background. The case was developed for an anatomy and physiology course, but it could also be used in nursing, kinesiology, sports medicine, pathophysiology, or other introductory-level biology courses.