For many children, especially those with reading difficulties, a motor-kinesthetic learning activity may be an effective tool to teach complex concepts (Gardner 1993). With this in mind, a team developed and tested a game designed to teach fourth- to sixth-grade children some basic principles of nervous system function by allowing the children themselves to model the nervous system signals. A formal test of the game led to the activities described in this article. This game is a great way to introduce such complex principles as motor versus sensory signaling, reflexes, and the effects of spinal cord injury.