In a large-enrollment, introductory biochemistry course for nonmajors, the authors provide students with formative feedback through practice questions in PDF format. Recently, they investigated possible benefits of providing the practice questions via an online game (Brainspan). Participants were randomly assigned to either the online game group or the PDF-only group. Both groups received identical practice questions and correct/incorrect feedback only, with no additional detail. They believed that the game might increase engagement with the material and improve performance on the examination. However, they found that the exam scores of the two groups did not differ.