Anatomy and Physiology I (A&P 1) has one of the highest failure and withdrawal rates on campus. To increase academic success, a course to supplement A&P 1 (Supplement) was developed and taught by anatomy and physiology faculty. Primary goals for the Supplement included (1) early identification of students at risk for failing or withdrawal; (2) understanding student demographics; (3) using a multifaceted approach in the classroom; and (4) developing a strong sense of community. A variety of activities were incorporated to address the needs of a diverse group of students. A two-part survey was administered during the first and last weeks of class. The survey assessed demographics of students and factors known to affect student academic performance. Results indicate that students who participated in the Supplement course achieved a grade of C or better at a much higher rate than those students who did not participate (63% vs. 38%). Students enrolled in the Supplement course were also retained at a higher frequency (89% vs. 64%). Survey results indicate that improvements in student success and retention were likely due to changes in student skills and behaviors as a result of participation in the Supplement.