Malaria, Lyme disease, Epstein-Barr syndrome, meningitis, syphilis, hepatitis B and HIV/AIDS—what do all of these diseases have in common? These belong to a group of over 100 microorganisms categorized as bloodborne pathogens. With the HIV epidemic and public awareness of Hepatitis B, coupled with confidentiality legislation, bloodborne pathogens came front and center on the public’s radar. Bloodborne pathogens also got the attention of middle and high school science teachers, due to hands-on activities such as check cell staining/observation and blood typing, along with general exposure to dried blood or fresh blood and more.