In their research, scientists generate, test, and modify scientific models. These models can be shared with others and demonstrate a scientist’s understanding of how the natural world works. Similarly, students can generate and modify models to gain a better understanding of the content, process, and nature of science (Kenyon, Schwarz, and Hug 2008). This article serves as a how-to guide for integrating model-based inquiry (MBI) and wikis into a biology unit on natural selection. Students learn about the content and process of science through modeling activities (Windschitl 2008; Neilson, Campbell, and Allred 2010) and building wikis.