We have all sat in classes in which a teacher made a difficult or abstract concept understandable by using an analogy. Science classes are full of abstract or challenging concepts that are easier to understand if they are related to something from our everyday experiences. Analogies can be useful instructional tools in each phase of the 5E instructional model. This article briefly describes the phases in the 5E model and provides suggestions for using analogies in each phase. Analogies from biology and chemistry classes are used to illustrate the author’s points.