Skip to main content
 

All or Nothing

A Case Study in Muscle Contraction

By Ryan T. Neumann, Collin J. Quinn, Brittany A. Whitaker, Sean T. Woyton, Breanna N. Harris

All or Nothing


 

Abstract

In this interrupted case study, students pose as an intern of a neuromuscular/skeletal specialist and discover how sarin and myasthenia gravis influence muscle function. Students are given background information about the patients and their situations, as well as results from blood tests. Students are asked incremental questions that build on each other with the end goal of students describing the process of muscle contraction, from motor neuron to sarcomere shortening, and learning what happens when parts of that process are disrupted. This activity was developed for use in a physiology course where the majority of the students were pre-medical, pre-nursing, or other allied health majors.

   

Date Posted

09/29/2016

Overview

Objectives

  • Explain the relationship that exists between nicotinic acetylcholine receptors along the post synaptic cleft/motor end plate and acetylcholine.
  • Explain the calcium ion flow into and out of the sarcoplasmic reticulum.
  • Identify the role of calcium in muscle contraction and describe its relationship with myosin and actin.
  • Compare and contrast the effects of having too little or too much acetylcholine and acetylcholine esterase in the synaptic cleft.

Keywords

muscle; sarin; sarcomere; contraction; NMJ; excitation-contraction; myasthenia gravis; neuromuscular junction; sliding-filament theory

  

Subject Headings

Biology (General)
Medicine (General)
Nursing
Physiology
Sports Science
Toxicology

EDUCATIONAL LEVEL

Undergraduate lower division, Undergraduate upper division

  

FORMAT

PDF

   

TOPICAL AREAS

N/A

   

LANGUAGE

English

   

TYPE/METHODS

Interrupted

 

 

Asset 2