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Abstract
This case study, designed for the “flipped” classroom, is divided into four parts that explore the etiology of Huntington disease. Students complete the first two sections before coming to class by watching videos and an interactive module from HHMI BioInteractive and answering a set of questions that require them to integrate prior knowledge of DNA replication with the more advanced genetics topics of trinucleotide repeat errors during DNA synthesis, which can lead to neurological and genetic disorders, in particular Huntington disease. In-class work begins with Part III, which features an inspiring mini-documentary produced by the authors about Auggie, an Afro-Hispanic boy diagnosed with juvenile Huntington disease (JHD). Part IV concludes the case with a look at novel therapeutic strategies using RNA interference. The case is suitable for use by undergraduate students enrolled in genetics, cell physiology, neuroscience or related courses.