Abstract
“Melanie Johnson” is a 32-year-old accountant who has moved to Green Bay, Wisconsin, from her hometown of Sarasota, Florida. For the first time in her life, she has been experiencing periods of depression, lethargy, and excessive sleeping. Students read about these symptoms then answer a set of directed questions designed to teach facts and principles of anatomy and physiology using reference books, textbooks, the Internet, and each other as sources of information. The case has been used in both a sophomore-level course in human anatomy and physiology and a senior-level course in general physiology.