This case study explores the 2016–2018 cholera outbreak in Yemen and how political and financial circumstances impacted relief efforts. Students research the basics of the Vibrio cholerae bacterium and then amplify their understanding in class through the use of a role-play activity representing a doctor-patient interaction. This is followed by a second in-class activity in which students participate in a simulation of a small town in war-torn Yemen illustrating how cholera spreads and the strains that are placed on the healthcare system. A PowerPoint presentation is used in class to help guide the activities. Additionally, the teaching notes include an optional post-class extension based on the cholera outbreak in London (“Cholera in the Streets”), which allows students to critically analyze factors within a fictional town and engage with public health policies surrounding outbreak scenarios. The case was designed for an advanced IB or AP high school biology class, or for use as part of an introductory college-level biology course.