This case study tells the story of “Skylar” and her mom “Angie” who suffers from persistent diarrhea. What begins as a seemingly acute case turns chronic after a few weeks and Angie is eventually diagnosed with lymphocytic colitis. Skylar has recently learned about immunity, inflammation, and intestinal function in her anatomy and physiology course. When searching for a diagnosis and treatment, she reviews the basics of inflammation, regulation by cytokines, and the unique inflammatory events seen in colonic tissue given its localized microanatomy. The case study further explores how the immune system can be harnessed through cytokines to treat chronic gut inflammation. This case study was developed to supplement an undergraduate anatomy and physiology course that covers immunology and the digestive system. It can also be expanded for use in an undergraduate senior-level immunology course.