This interrupted case study is based on a PBS NOVA episode covering events in the summer of 1982 when seven California heroin users mysteriously and suddenly developed Parkinson’s disease. The video, which is shown in class and paused at several designated points for guided class discussion and mini-lectures, provides details about the neurobiology of Parkinson’s disease as well as fundamental principles of the neurobiology of movement. Students consider the evidence that environmental toxins can contribute to Parkinson’s disease susceptibility. By extending the case to an additional class period, students explore pesticides and other chemicals in their environment and the possible impacts on their neurological systems due to exposures. The case concludes with a discussion of current ideas about gene-environment interactions and considerations for current Parkinson’s treatments and research. This case is best suited for use by advanced high school students or early undergraduate students, but it could be adapted for upper-level neuroscience majors as well.