As nonliving entities, viruses face specific challenges when replicating in a host.  Avoiding the host immune system is something that every virus aims for in order to successfully reproduce itself and infect another host.  Many viruses replicate quickly and leave the host before a full immune response has been achieved.  In contrast, the Herpesviridae remain in the host for life, using latency and periodic reactivation events to spread viral particles while avoiding the memory immune response.  This case study explores specific immune evasion mechanisms of herpes simplex virus-1 (HSV-1), which is the causative agent of cold sores and is estimated to be present in upwards of 50% of the human population.  The case also considers anti-viral therapies and the resulting effects on HSV-1 replication and dissemination. Written to promote interdisciplinary connections between an upper-division virology class and an immunology class, the case is the second case in a set of three cases. The other two cases, also published on this site, include "Chickens and Humans and Pigs... Oh My!" and "Retro Goes Modern: The Evolution and Evasive Maneuvers of HIV."