In this “clicker case,” students are introduced to Abby, a college student who has been diagnosed with ovarian cancer. As they follow Abby’s plight, students learn about basic cellular and genetic mechanisms that are responsible for cancer formation, gaining a general understanding of how cells become cancerous through genetic mutations, how cancers can spread throughout the body by metastasizing, and how modern medicine is currently treating patients diagnosed with cancer through surgery, radiation, and chemotherapy. Developed for use in a large introductory biology course, the case consists of a PowerPoint (~2MB) presented in class that is punctuated by multiple-choice questions the students answer using “clickers.” The case can be adapted for use without these technologies.