This directed case study is designed to improve the understanding of SARS-CoV-2 infection. Laboratory test results from real patients are used to tell the story of three individuals in a family who test positive for COVID and are hospitalized during the coronavirus (2020) outbreak in the United States. The first patient is an 85-year-old male with a pre-existing cardiac condition; the second is an otherwise healthy 50-year-old male with no medical history; and the third is an 80-year-old female without any major illness. The timeline and progression of infections, interventions, and outcomes of these patients are discussed. The sex-specific differences in contracting COVID and the severity of infection are also highlighted. The case is ideally suited for students in upper-level biology and health science courses to learn basic pathophysiological terminology, and to research the symptoms, susceptibility, mechanism of action of SARS-CoV-2, COVID-related pulmonary distress, and extra-pulmonary complications. The case concludes with an assignment that provides students with an opportunity to reflect on the progress made in designing novel treatments.