This set of mini cases is designed to develop students’ understanding of cell structure compartmentalization, spatial arrangement, and organelle coordination. Each mini case consists of a scenario, a modeling activity involving roleplay, and a follow-up set of questions. These mini cases may be used in any combination, although it is most likely that an instructor will choose just one, depending on the topic of interest: protein synthesis and endomembrane transport system; photosynthesis and cellular respiration; or phagocytosis of Streptococcus through bulk transport. Through the process of modeling, students gain a better understanding of spatial arrangements, functions, and coordination of cell structures; they also are more likely to avoid the common misconception that organelles act as independent entities, when instead these structures perform as highly organized networks within the larger context of the cell. These mini cases were developed for an introductory biology course primarily taken by pre-health majors and are best implemented after students have illustrated a firm understanding of the four classes of macromolecules and the functional intricacies of phospholipid bilayers.