This case study uses a PowerPoint presentation to guide students through two activities designed to teach them about the basics of coronavirus diagnosis and transmission. The first activity involves a set of five “clicker questions” that students answer using either a personal response system, online polling application, or show of hands as they consider symptoms and test results of a hypothetical patient. The second activity is an outbreak simulation in which students consider the spread of a pathogen in various geographical settings and from different perspectives. Students work together to draft a list of precautions that could be taken to limit the spread of the disease and minimize healthy individuals’ risk of contracting it. The simulation is designed for a biology lesson pertaining to outbreaks. Although coronavirus is used as the model, the concepts of disease transmission and prevention covered in this case are relevant to many diseases.