This case study presents a brief account of the life of John F. Kennedy, 35^th President of the United States (1961-63). Kennedy suffered from Addison's disease, an endocrine disorder characterized by inadequate production of adrenal steroid hormones, such as cortisol and aldosterone. Although attempts were made during his lifetime to hide his condition since it was thought to threaten his political career, the disease contributed to health complications that often left him weak or in pain. By answering questions about Kennedy’s symptoms, students consider the physiological consequences of inadequate hormone secretion and apply their understanding of negative feedback regulation to the hypothalamic-pituitary-adrenal gland axis. The case would be appropriate for use in undergraduate classes in human anatomy and physiology, human physiology, animal physiology, or endocrinology.