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A Stressful Semester

The Regulation of Cortisol Release

By Juanita K. Jellyman, Hannah Ticheli

A Stressful Semester


 

Abstract

This case study tells the story of “Claire,” an undergraduate student experiencing symptoms commonly attributed to stress as she juggles a demanding academic schedule, a part-time job, and the challenges that come from living away from home for the first time. After Claire’s primary care provider refers her to an endocrinologist, her test results reveal that she has a small pituitary adenoma that is secreting adrenocorticotropic hormone (ACTH) and causing her plasma concentration of cortisol to be high. Students are asked to relate Claire’s symptoms to the physiological consequences of excess cortisol secretion and to create a treatment plan for her Cushing’s disease. The case would be appropriate for use in undergraduate classes in human anatomy and physiology, human physiology, animal physiology, or endocrinology.

   

Date Posted

08/16/2021

Overview

Objectives

  • Identify the functional zones of the adrenal cortex.
  • Define stress.
  • Describe the functions of cortisol.
  • Explain how steroid hormones are transported in the blood.
  • Recognize where steroid hormone receptors are located.
  • Diagram negative feedback regulation of cortisol release.
  • Recognize that cortisol secretion has a circadian rhythm.
  • Differentiate between primary and secondary hypersecretion of a hormone.
  • Differentiate between Cushing’s disease and Cushing’s syndrome.
  • List the clinical symptoms of Cushing’s disease and Cushing’s syndrome.
  • Relate the symptoms of Cushing’s disease to hypersecretion of cortisol.
  • Formulate a treatment plan for a patient with Cushing’s disease.

Keywords

Adrenal cortex; cortisol; glucocorticoid; ACTH; HPA axis; Cushing’s disease; Cushing’s syndrome; steroid; physiological stress; stress; hormones; pituitary adenoma

  

Subject Headings

Biology (General)
Physiology

EDUCATIONAL LEVEL

Undergraduate lower division, Undergraduate upper division

  

FORMAT

PDF

   

TOPICAL AREAS

N/A

   

LANGUAGE

English

   

TYPE/METHODS

Directed, Discussion, Interrupted

 

 

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