This case study consists of a role-play activity designed to simulate interactions between a patient and a health care provider. The patient, played by the instructor, describes symptoms associated with systemic lupus erythematosus and lupus nephritis (SLE and LN) as clinical complaints. The students act in the role of health care providers and are tasked with asking appropriate questions as part of a clinical evaluation. After the initial patient visit, students analyze the presented subjective data, observations, and laboratory results to formulate a diagnosis. At the culmination of the activity, students create their own scenarios taking turns to act as patients and providers with their peers. This case study simulates a real life clinical scenario exposing students to practice each level of Miller’s triangle of clinical competence in a safe classroom setting. This case can be utilized in any course addressing pathophysiology, health, and clinical work-up skill development. Due to the open-ended nature of the activity, an answer key is not available.