WebQuests and the 5E learning cycle are titans of the science classroom. These popular inquiry-based strategies are most often used as separate entities, but the author has discovered that using a combined WebQuest and 5E learning cycle format taps into the inherent power and potential of both strategies. In the lesson, “Clash of the Titans,” there are two other titans involved—titans of the animal world—alligators and pythons. Through this combined WebQuest/5E lesson, students learn about predator-prey relationships and human effects on the environment through introduced species.