Basic knowledge and adoption of biosafety guidelines, including disinfection and sterilization techniques, are a necessary component in high school biology laboratories. This is especially important if students or instructors are working with growing cultures or are involved in recombinant DNA activities. Also of concern is the growing presence of bloodborne pathogens, other potentially infectious materials (OPIMSs), methicillin-resistant Staphylococcus aureus (MRSA), and immune-suppressed or compromised students and teachers. This month’s Safer Science column addresses how these “bugs” can be kept under control.