“I’ve never heard of a small speck of dust that is able to yell” says Horton of a sound he hears well (Geisel 1954). It is always valuable to connect science to student’s interests and their everyday world—so what better way to teach concepts relating to sound than to read Horton Hears a Who by Dr. Seuss? Here the authors present several activities that can be integrated with this timeless story, in which students use the process of scientific investigation, such as asking questions, forming a hypothesis, testing ideas, analyzing data, forming conclusions, and communicating results.