You might wonder why today’s science teachers need to keep current with the latest technologies available for special education students. When you consider that more than 50 million Americans are identified as having a disability, classroom technology applications for special education students is crucial (Sharp 2002). Especially for those that would generally not be able to participate in scientific activities without the use of the latest technologies. This article describes computer-assisted instruction and assistive technologies that are available for students with disabilities. It also includes an assistive technology glossary.