College and university science programs generate hazardous waste that must be dealt with and disposed of in accordance with state and federal regulations. During a recent renovation and addition project for the State University of New York at Plattsburgh (SUNY Plattsburg), the author was contracted to analyze existing regulations, research best practices at similar institutions, evaluate SUNY Plattsburg’s facilities and procedures, and make recommendations for facilities modifications during the construction process. This article describes the findings of these efforts, describes sources of regulatory and other useful information, and lists the recommendations made to SUNY Plattsburgh.