An interdisciplinary approach to teaching involves leveraging the different perspectives of each discipline to better understand an issue or problem. The most ideal topics for interdisciplinary study are those whose very nature is also interdisciplinary. Nanoscience—which combines biology, chemistry, physics, engineering, and mathematics—is one such topic. This article presents the use of nanoscience as a theme for the interdisciplinary study of science and mathematics. An example curriculum and thoughts about an inquiry instructional method are included.