Childhood obesity and its long-term health implications should be of major concern to science educators. In an effort to support teachers and youth about this growing problem, a five-unit, 19-lesson module entitled Choice, Control, and Change (C3) was developed at Teachers College Columbia University. C3 is a standards-driven and inquiry-based curriculum that is framed around the driving question, “How can we use scientific evidence to help us make healthy food and activity choices?” The curriculum provides teachers and students with rigorous, yet relevant investigations into how an understanding of biology, the environment, and personal behaviors impacts weight and health.