Problem-based learning (PBL) is a powerful vehicle for inquiry-based learning in which students use an authentic problem as the context for an in-depth investigation of what they need and want to know (Checkly, 1997). This article presents ten steps to PBL, which are based on a popular medical school model that involves students in constructing understanding through critical and creative thinking and promotes collaboration and autonomy in learning (Barrows, 1986).