Claude Monet meets the world of science through Histro-Art, a concept that was conceived from the impressions of an 11th and 12th-grade college preparatory human anatomy and physiology class who were studying histology using a micro-video system. As they observed a slide of smooth muscle, one student noticed the resemblance to impressionist art, and thus the concept was born. In this engaging activity, students observe microscopic slide tissue and interpret impressionism theory using various mediums to create their own art pieces. It is sure to leave them with a lasting "impression" of the connection between art and science.