An interactive notebook can be a powerful instructional tool, allowing students to take control of their learning while processing information and engaging in self-reflection. The three-part learning cycle of an interactive notebook makes it easy to use and integrate into the science lesson. The basic ideas has its roots in a number of programs (TCI 2000; AVID 2007), but applying knowledge about how students learn science can make this an even more effective tool. In addition to presenting techniques for design, implementation, and assessment, this article describes how interactive notebooks empower students for science achievement.