In addition to the Occupational Health and Safety Administration (OSHA) personal protective equipment (PPE) standard—OSHA Laboratory Standard 29CFR 1910.132—and other professional prudent practices, many states have protective eye devise statutes. PPE is third in the hierarchy approach to dealing with safety. In this priority list, the employer must first evaluate the feasibility of engineering controls and administrative procedures before considering the use of PPE. This month’s Safer Science column includes components that reflect the body of the PPE assessment that should be addressed by teachers, students, and supervisors in science laboratories or field experiences.