Blake is sick.  With his background in the sciences and a little help from the Internet, he should be able to do a self-diagnosis.  Or can he?  As the case unfolds, students follow the course of Blake's illness.  Part I of the case details the initial signs of Blake's illness and his attempts at self-diagnosis.  Students are asked to identify a potential list of disorders based on the limited symptoms presented.  Part II describes the results of the doctors’ physical exam and initial laboratory tests.  At this point, students should be able to narrow the list of possibilities.  Part III reveals the cause of the illness and the course of treatment.  The case works well as an interrupted case that can be assigned to individual students or student teams.  It was written for a School of Pharmacy microbiology course, but could easily be used in a medical microbiology or infectious diseases course.