“Scott” and “Celeste” want to have another baby, but their plans go awry when Celeste miscarries twice. Students follow the couple’s struggle in this case study to learn about meiosis, independent assortment, chromosomal rearrangements, balanced translocation, and assisted reproductive technologies. The case involves the analysis of a real karyotype showing a male with a balanced translocation between chromosomes 9 and 22. Using this karyotype, students draw possible arrangements of chromosomes in the metaphase plate during meiosis I and make predictions about which of Scott’s gametes can produce viable offspring. The case was written with the intent of providing a real-world application of a variety of concepts covered in introductory genetics or biology while raising awareness of a common, yet misunderstood phenomenon, miscarriage. The goal is to provide students with a meaningful and relevant educational experience that will contribute to a reduction in pregnancy loss, improve care for bereaved parents, and promote equitable access to medical advancements.