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The Chemistry of Cooley's Anemia

By Christopher T. Bailey, Mohammad Mahroof-Tahir

The Chemistry of Cooley's Anemia


 

Abstract

Young parents, Max and Andrea Forest, learn that their child is suffering from the genetic disorder, thalassemia. Treatment requires a lifetime commitment to whole blood transfusion and chelation therapy, both of which must be administered on a daily to weekly basis. Students read the case, answer a series of questions, and then decide how they would treat the child if they were the parents. The case was developed to introduce students to the role of metal ions and coordination chemistry in biological systems. It would be appropriate for use in courses in biochemistry, molecular biology, bioinorganic chemistry, and bioethics, among others.

   

Date Posted

03/28/2003

Overview

Objectives

  • Understand and discuss the causes, symptoms, and treatment of the genetic disorder thalassemia.
  • Understand and discuss the role of iron in the body.
  • Understand and discuss the use of chelating agents in the treatment of iron overload.

Keywords

Cooley's anemia; thalassemia; genetic disorder; genetic disease; hemoglobin; iron transport and storage in the body; iron overload; chelation therapy; deferoxamine; Desferal; metal ions; coordination chemistry; bioethics

  

Subject Headings

Biochemistry
Inorganic Chemistry
Molecular Biology

EDUCATIONAL LEVEL

Undergraduate lower division, Undergraduate upper division

  

FORMAT

PDF

   

TOPICAL AREAS

Ethics

   

LANGUAGE

English

   

TYPE/METHODS

Dilemma/Decision

 

 

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