Ellie is a struggling college student on the brink of failing her physiology course; not surprisingly, she exhibits many classic signs of stress. However, a visit to the health clinic reveals that she may be suffering from more than just stress. In this interrupted case, students first read about Ellie’s signs and symptoms and use a series of guided questions to make predictions about her test results and diagnosis. After Ellie receives her diagnosis, students must then explain the test results based on their knowledge of the function and regulation of the thyroid gland, and investigate various options for treatment. Designed for a two-semester undergraduate anatomy and physiology course, the case could be adapted for use in an undergraduate physiology or endocrinology course.